The global science conversation depends on the flow of information from its source to where it can be analyzed and understood, like a vast circulatory system transporting vital knowledge. For the U.S. Department of Energy, that vital knowledge is transported by ESnet. ESnet staff ensure that challenging scientific data transfer needs are met via transatlantic links thousands of kilometers of fiber and hundreds of peering relationships. Our latest network generation, ESnet6 is a significant national investment, driving major scientific discovery through an exponential increase in data capacity that can flexibly grow to meet demand. Automation for reliable performance, advanced cybersecurity capabilities to prevent disruptions, new technologies and real-time telemetry monitoring data while still in motion, and cutting-edge research programs supporting unhindered innovation. ESnet is a network made possible by our world-class team, our infrastructure, and the global science community, ensuring that scientific progress is unconstrained by geography. Science is a conversation, a conversation at the speed of ESnet.